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NEUROLOGY 1979;29:720
© 1979 American Academy of Neurology

Cholinergic dysautonomia and Eaton-Lambert syndrome

Allan E. Rubenstein, M.D., Steven H. Horowitz, M.D. and Adam N. Bender, M.D.

Department of Neurology, Mount Sinai School of Medicine, City University of New York, and the Neurology Service of Mount Sinai Hospital, New York.

Cholinergic autonomic function was abnormal in a 47-year-old woman with Eaton-Lambert syndrome (ELS), not associated with carcinoma. Pupillary constriction to light and accommodation, sweating, lacrimation, and salivation were all affected. There was no evidence of Sjogren syndrome or botulinum intoxication. The defect of acetylcholine release from presynaptic terminals in the Eaton-Lambert syndrome may not be restricted to the neuromuscular junction of skeletal muscle.






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