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Intravenous phenytoin in acute treatment of seizures

Department of Neurology, University of Minnesota School of Medicine, and the Departments of Neurology, Hennepin County Medical Center and St. Paul-Ramsey Medical Center, Minneapolis, MN.

Large doses of phenytoin were administered on 159 occasions to 139 adult patients. Most patients had had more than three seizures or were in status epilepticus. Based on response to treatment, patients could be divided into two groups. Those with excellent response (recurrent seizures, 10%; mortality, 1%) included known epileptics with exacerbation of seizures (n = 79, atypical alcohol withdrawal (61, or miscellaneous conditions (17). Those with poor results (recurrent seizures, 57%; mortality, 38%) included patients with anoxic or metabolic encephalopathy (14), stroke or other vascular disease (14), brain tumor (5), or trauma (5).

Address reprint requests to Dr. Cranford, Department of Neurology, Hennepin County Medical Center, 701 Park Ave. So., Minneapolis, MN 55415.

This study was supported by NINCDS Contract No. N01-NS-5-2327.

This paper was presented at the thirtieth annual meeting of the American Academy of Neurology, Los Angeles, April 1978.

Accepted for publication April 17, 1979.

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