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NEUROLOGY 1979;29:1445
© 1979 American Academy of Neurology

Phenobarbital dosage for control of neonatal seizures

Lawrence A. Lockman, M.D., Robert Kriel, M.D., Darwin Zaske, Pharm. D., Theodore Thompson, M.D. and Norman Virnig, M.D.

Division of Pediatric Neurology, Department of Neurology (Dm Lockman and Kriel), the Department ofPediatrics (Dr. Thompson), and the College of Pharmacy (Dr. Zaske), University of Minnesota, Minneapolis, and the Departments ofpediatrics and Neurology (Drs. Kriel and Virnig) and the Department of Pharmacy (Dr. Zaske), St. Paul Ramsey Hospital, Sit. Paul, Minnesota.

The relationship of the initial phenobarbital dose to weight, gestational age, blood level, and seizure control was studied in 39 neonates. The blood level was proportional to the dosage per kilogram, and was not related to weight or gestational age. Seizures remitted only at blood phenobarbital concentrations above 16.9 pg per milliliter. Therapeutic levels can be achieved by the intravenous or intramuscular administration of 16 to 23 mg per kilogram of phenobarbital.

Address reprint requests to Dr. Lockman, Division of Pediatric Neurology, University of Minnesota Medical School, Box 486, Mayo Memorial Building, 420 Delaware Street SE, Minneapolis, MN 55455.

Supported in part by funds fhm the Minnesota Medical Foundation and research grants through the Comprehensive Epilepsy Program, University of Minnesota (NO 1-NS-5-2327) and the Medical Education and Research Foundation, St. Paul Ramsey Hospital.

Presented in part before the Child Neurology Society, Monterey, California, October 29, 1976.

Accepted for publication April 23, 1979.




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