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NEUROLOGY 1978;28:59-67
© 1978 American Academy of Neurology

Some factors influencing the proliferation and differentiation of myelin-forming cells

Richard P. Bunge, Mary Bartlett Bunge and Michael Cochran

Departments of Anatomy and Neurobiology. Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO.

Fundamental questions arising from study of the multiple sclerosis lesion are: (1) why themyelin-forming oligodendrocyte is adversely affected; and (2) what factors might induce the proliferation and differentiation of replacement oligodendrocytes. This paper discusses factors that influence the number and differentiative capacity of myelin-forming cells both in the central nervous system (CNS) and the peripheral nervous system (PNS). New experiments utilizing cultures of fetal rat sensory and autonomic ganglia are also herein reported. It has been found that in cultures free of fibroblasts, normal Schwann cell proliferation and ensheathment of axons require contact with a collagen substrate and may be facilitated by a medium containing chick embryo extract. This demonstration of a connective tissue requirement for normal Schwann cell function raises the question of whether additional factors are necessary for normal oligodendrocyte activity.

Dr. Bunge's address is Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO.

This research was supported by NIH Grant NS-09923. Dr. Cochran is a Postdoctoral Trainee under NIH Grant 56019.

Accepted for publication May 8, 1978.






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