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Anamnestic studies in multiple sclerosis

A relationship between familial multiple sclerosis and neoplasia

Department of Neurology, University of Arizona College of Medicine and University Hospital, Tucson, AZ.

A survey of family histories of malignant neoplasia in multiple sclerosis (MS) patients indicates that a positive history of cancer in near relatives is present in 44 percent of patients and 46 percent of controls. However, those MS patients having such a positive history were much more likely than others to also have a family history of MS. Contrariwise, MS patients with a positive family history of MS had a significantly higher rate ofcancer in first degree relatives (71 percent) than others. There was a trend indicating less cancer in families of MS patients possessing the HLA-B7 and DW2 histocompatibility antigens.

Dr. Sibley's address is Arizona Health Sciences Center, Tucson, AZ 85724.

Supported in part by grant RG 1048-A-11 from the National Multiple Sclerosis Society.

Accepted for publication May 8, 1978.