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Corpus callosum and propagation of afterdischarge to contralateral cortex and thalamus

Neurosurgery Section, Veterans Administration Hospital. Long Beach, and the Division of Neurological Surgery, University of California, Irvine, California.

The patterns of seizure spread were investigated in cats with experimental seizure foci in the motor cortex. Recordings were made with tungsten microelectrodes. When convulsive activity developed at the focus, there was activation of the ipsilateral thalamus before there was propagation of afterdischarge to the opposite hemisphere. Section of the corpus callosum did not prevent propagation of afterdischarge to the contralateral thalamus, and prolonged the circulation of abnormal activity between the cortex and ipsilateral and contralateral thalamus.

Dr. Kusske's address is University of California, Irvine Medical Center, 1011 City Drive, South, Orange CA 92668.

This study was supported by the Medical Research Service of the Veterans Administration.

Accepted for publication March 21, 1978.