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Effect of valproic acid on spike and wave discharges in patients with absence seizures

Neurology Service, Veterans Administration Hospital, and the Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.

Twenty-five patients with absence seizures were treated with valproic acid in doses from 17 to 62.5 mg per kilogram per day. Nineteen patients experienced reduction of spike and wave discharges; in 11 it was greater than 75 percent. Twenty-one patients had a reduction of the total time of spike and wave discharge. Four patients had increase of spike and wave discharges. Nineteen patients had fewer absence seizures. There was no correlation between plasma concentration of valproic acid and EEG change, but clinical improvement occurred when plasma levels of valproic acid reached 50 to 60 µg per milliliter.

Reprint requests should be sent to L. J. Willmore, M.D., Neurology Service, Veterans Administration Hospital, Gainesville, FL 32602.

This work was supported by the Medical Research Service of the Veterans Administration and the Epilepsy Research Foundation of Florida, Inc. Dr. Villarreal is sponsored by ANUIES, Mexico City, Mexico and the Epilepsy Research Foundation of Florida, Inc.; Dr. Bruni is sponsored by the Ministry of Health, Ontario, Canada.

Accepted for publication May 1, 1978.

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