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Huntington disease

Normal lipid composition of purified neuronal perikarya and whole cortex

Saul R. Korey Department of Neurology, Department of Neuroscience, Department of Pathology (Neuropathology Division), and the Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.

This is the first report of the lipid composition of human neurons. Neuronal perikarya were isolated from frozen autopsy samples of the cerebral cortex of two persons with Huntington disease and two normal controls. These were analyzed for total lipid, individual lipids, and gangliosides. No differences were detected between diseased and normal cells. In addition, gray matter samples from the same patients, and one additional patient and control sample, were analyzed and found not to differ. Thus the ultrastructural abnormalities seen in cortical biopsies are not reflected in the concentration of the major lipid classes.

Reprint requests should be addressed to Dr. Norton, Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461.

This work was supported by USPHS grants NS-03356, NS-02476, NS-08180, and GM 19100-4836.

Accepted for publication April 25, 1977.