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Progressive multifocal leukoencephalopathy

Failure of response to transfer factor and cytarabine

Departments of Neurology, Pathology, and Medicine, University of Texas Health Science Center at Houston (Medical School), and Hermann Hospital, Houston, Texas.

A 57-year-old woman with a 2-year history of neurologic symptoms was shown on brain biopsy to have progressive multifocal leukoencephalopathy. Although cell-mediated immune mechanisms were impaired, no underlying disease was found. The administration of transfer factor enhanced cell-mediated immunity, but the neurologic symptoms did not improve. Separate courses of glucocorticoids and cytarabine were associated with rapid neurologic deterioration.

Reprint requests should be addressed to Dr. Van Horn, P.O. Box 20708, Houston, TX 77025.

Accepted for publication January 25, 1978.

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