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NEUROLOGY 1978;28:754
© 1978 American Academy of Neurology

The Harvard Cooperative Stroke Registry

A prospective registry

J. P. Mohr, Louis R. Caplan, John W. Melski, Robert J. Goldstein, Gary W. Duncan, J. P. Kistler, Michael S. Pessin and Howard L. Bleich

Stroke Service and Neurology Service, Massachusetts General Hospital, the Beth Israel Hospital, and the Thorndike Laboratory and Department of Medicine, Beth Israel Hospital, Boston.

Data from 694 patients hospitalized with stroke were entered in a prospective, computer-based registry. Three hundred and sixty-four patients (53 percent) were diagnosed as having thrombosis, 215 (31 percent) as having cerebral embolism, 70 (10 percent) as having intracerebral hematoma, and 45 (6 percent) as having subarachnoid hemorrhage from aneurysm or arteriovenous malformations. The 364 patients diagnosed as having thrombosis were divided into 233 (34 percent of all 694 patients) whose thrombosis was thought to involve a large artery and 131 (19 percent) with lacunar infarction. Many of the findings in this study were comparable to those in previous registries based on postmortem data. New observations include the high incidence of lacunes and cerebral emboli, the absence of an identifiable cardiac origin in 37 percent of all emboli, a nonsudden onset in 21 percent of emboli, and the occurrence of vomiting at onset in 51 percent and the absence of headache at onset in 67 percent of hematomas.

Dr. Mohr's address is Department of Neurology, College of Medicine. University of South Alabama Medical Center, 2451 Fillingim St., Mobile, AL 36617.

Presented in part at American Academy of Neurology meetings in Miami, 1975, Toronto, 1976, and Atlanta, 1977.

This study was supported by grants HS 00188 from the National Center for Health Services Research, HRA, and IF 22 NS 01970-01 and NS 10828-01Al from the National Institutes of Health.

Accepted for publication March 23, 1978.




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