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Epidemiology of Guillain-Barré syndrome

Uri Leibowitz Neuroepidemiology Unit, Department of Neurology, Hadassah University Hospital, Jerusalem, Israel, and the Neuroepidemiology Unit, Department of Neurology, Temple University, Philadelphia. Pennsylvania.

From 1969 through 1972, a nationwide search for cases of Guillain-Barré syndrome (GBS) in Israel revealed 89 patients. The average annual age-adjusted incidence was 0.75 per 10⁵ persons. Overall incidence of the syndrome was similar in Jewish groups of diverse ethnic backgrounds. Arabs had a lower overall incidence than Jews (0.46 per 10⁵ persons), perhaps attributable to fewer Arabs at risk in older age groups. Peaks of incidence occurred among individuals over 60 and under 4 years of age when all cases were combined. No clear seasonal or geographic clustering of GBS was evident in Israel during the 4 years of this study. The incidence of GBS in the present study agrees with previous population-based estimates.

Reprint requests should be addressed to Dr. Alter, Neuroepidemiology Unit, Department of Neurology, Temple University, Philadelphia, PA 19140.

This investigation was supported by Bio-Medical Research Grant 5-S01-RR05417-15, Temple University.

Accepted for publication October 19, 1977.

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