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NEUROLOGY 1978;28:678
© 1978 American Academy of Neurology

Central nervous system lesions in childhood leukemia

CARL J. CROSLEY, M.D., LUCY BALIAN RORKE, M.D., AUDREY EVANS, M.D. and MICHAEL NIGRO, D.O.

Departments of Pathologic Anatomy and Oncology, The Children's Hospital of Philadelphia.

Central nervous system (CNS) lesions were found in 85 of 91 children with acute leukemia. Cerebral atrophy was the most common lesion, occurring in 65 percent. Atrophy was most severe in children treated with intrathecal methotrexate alone or in combination with radiation therapy, in children youngest at time of onset of leukemia, and in children in whom duration of leukemia was shortest. Longer duration was the determining factor among children who were older at onset. Lesions previously reported by other investigators, such as leptomeningeal infiltration of leukemic cells, infection, hemorrhage, degenerative grey and white matter disease and leukoencephalopathy were also seen. Central pontine myelinolysis occurred in four children.

Dr. Rorke's address is The Children's Hospital of Philadelphia, Philadelphia, PA 19104.

This study was supported in part by grants CA 14489 and CA 11796 from the National Institutes of Health.

Accepted for publication July 20, 1977.




This article has been cited by other articles:


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 J Child NeurolHome page
F. S. Silverstein and M. V. Johnston
A Model of Methotrexate Encephalopathy: Neurotransmitter and Pathologic Abnormalities
J Child Neurol, October 1, 1986; 1(4): 351 - 357.
[Abstract] [PDF]


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