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NEUROLOGY 1978;28:670
© 1978 American Academy of Neurology

Studies of sarcolemmal integrity in myopathic muscle

W. G. BRADLEY, M.A., B.Sc., D.M., F.R.C.P. and J. J. FULTHORPE, F.I.M.L.S.

Department of Neurology, University of Newcastle upon Tyne, and the Muscular Dystrophy Research Laboratories, Newcastle General Hospital, Newcastle upon Tyne, England.

Studies of sarcolemmal integrity with extracellular Procion Yellow gave evidence of structural defects in a high percentage of muscle fibers in Duchenne dystrophy and in vitamin E-deficiency myopathy in the guinea pig. The dye entered fibers in these conditions more often than in controls. Myofibrillary clumping occurred in the region of major penetration of the dye. It seems likely that sarcolernmal defects occur in vivo in these conditions, allowing the entry of high concentrations of calcium into the sarcoplasm with consequent fiber damage. The biochemical basis of these sarcolemmal defects remains to be elucidated. Our procedure for biopsy of the vastus medialis muscle may prove useful in preparing a limb muscle for in vitro physiologic studies.

Dr. Bradley's address is Department of Neurology, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, England.

This work was supported by grants from the Muscular Dystrophy Group of Great Britain, the Muscular Oystrophy Association (USA), and the Medical Research Council of the United Kingdom.

Accepted for publication July 18, 1977.




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