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Gamma hydroxybutyrate in the monkey

II. Effect of chronic oral anticonvulsant drugs

Department of Pediatrics and the Clinical Research Laboratory, USAF Medical Center, Keesler AFB, Mississippi, and the Department of Pediatrics, University of Alabama in Birmingham Medical Center, Birmingham, Alabama.

Gamma hydroxybutyrate (GHB) was administered intravenously to monkeys that had been pretreated orally for 2 weeks with various anticonvulsant drugs or with L-DOPA at different dosage levels. Continuous electroencephalographic (EEG) monitoring was performed during and after GHB administration. Blood was assayed for GHB and for the anticonvulsant drug the animal was receiving. The EEG and behavioral changes produced by GHB were improved by ethosuximide and phenobarbital, made worse by phenytoin, and unchanged by L-DOPA.

Dr. Snead's address is Room 202, Children's Hospital, 1601 Sixth Avenue, South, Birmingham, AL 35233.

Presented in part at the twenty-ninth annual meeting of the American Academy of Neurology, Atlanta, Georgia, April 1977.

Accepted for publication October 10, 1977.

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