Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SNEAD, O. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SNEAD, O. C., III
NEUROLOGY 1978;28:636
© 1978 American Academy of Neurology

Gamma hydroxybutyrate in the monkey

I. Electroencephalographic, behavioral, and pharmacokinetic studies

O. CARTER SNEAD, III, M.D.

Department of Pediatrics and the Clinical Research Laboratory, USAF Medical Center, Keesler AFB, Mississippi, and the Department of Pediatrics, University of Alabama in Birmingham Medical Center, Birmingham, Alabama.

Gamma hydroxybutyrate (GHB) was administered to adult and prepubescent rhesus monkeys intravenously in varying dosages while an electroencephalogram (EEG) was recorded from scalp electrodes and the body core temperature was monitored. Blood and cerebrospinal fluid samples were assayed for gamma hydroxybutyrate. GHB produced a trancelike stupor in all the monkeys, associated with marked EEG changes and hypothermia. There was a striking age specificity in that prepubescent rhesus monkeys responded to a lower threshold dosage, had a higher incidence of myoclonic jerking, and showed characteristic EEG changes not seen in the adult animals. The EEG-behavioral changes paralleled the hypothermia. There was good correlation between the serum levels of GHB and the EEG-behavioral effects. These studies suggest that the GHB-treated monkey may have utility as a petit ma1 seizure model.

Dr. Snead's address is Room 202, Children's Hospital, 1601 Sixth Avenue, South, Birmingham, AL 35233.

Accepted for publication October 10, 1977.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
X. Ren and I. Mody
{gamma}-Hydroxybutyrate Reduces Mitogen-activated Protein Kinase Phosphorylation via GABAB Receptor Activation in Mouse Frontal Cortex and Hippocampus
J. Biol. Chem., October 24, 2003; 278(43): 42006 - 42011.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
K. M. Gibson, E. Christensen, C. Jakobs, B. Fowler, M. A. Clarke, G. Hammersen, K. Raab, J. Kobori, A. Moosa, B. Vollmer, et al.
The Clinical Phenotype of Succinic Semialdehyde Dehydrogenase Deficiency (4-Hydroxybutyric Aciduria): Case Reports of 23 New Patients
Pediatrics, April 1, 1997; 99(4): 567 - 574.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. L. Chambliss, D. L. Caudle, D. D. Hinson, C. R. Moomaw, C. A. Slaughter, C. Jakobs, and K. M. Gibson
Molecular Cloning of the Mature NAD[IMAGE]-dependent Succinic Semialdehyde Dehydrogenase from Rat and Human
J. Biol. Chem., January 6, 1995; 270(1): 461 - 467.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
O. Snead 3rd and L. Bearden
Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin
Science, November 28, 1980; 210(4473): 1031 - 1033.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1978 by AAN Enterprises, Inc.