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NEUROLOGY 1978;28:626
© 1978 American Academy of Neurology

Chlordecone intoxication in man

1. Clinical observations

JOHN R. TAYLOR, M.D., JOHN B. SELHORST, M.D., SIDNEY A. HOUFF, M.D. and A. JULIO MARTINEZ, M.D.

Department of Neurology (Drs. Taylor, Selhorst, and Houff) and the Division of Neuropathology (Dr. Martinez), Medical College of Virginia, Richmond, Virginia.

Industrial overexposure to chlordecone, an organochlorine insecticide, caused tremor in 76 of 148 exposed workers. Chlordecone was absorbed through oral, respiratory, and dermal routes, the last possibly the most significant. Epidemiology of this incident disclosed low-level, wide spread environmental exposure of man to chlordecone. In 23 workers with chronic chlordecone intoxication, tremor was associated with opsoclonus, pleuritic pain and arthralgia. No seizures were reported. The site of action of chlordecone on the central nervous system is unknown. It concentrates inhuman adipose and hepatic tissue but is not biodegradable, either in humans or elsewhere in nature.

Reprint requests should be addressed to Dr. John R. Taylor, Department of Neurology, Medical College of Virginia, P.O. Box 698, Richmond, VA23298.

Presented in part at the twenty-eighth annual meeting of the American Academy of Neurology, Toronto, Canada, April 26 to May 1, 1976.

Dr. Martinez's present address is Department of Pathology (Neuropathology), School of Medicine, University of Pittsburgh, Pittsburgh, PA 13261.

Accepted for publication August 4, 1977.






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