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NEUROLOGY 1978;28:592
© 1978 American Academy of Neurology

Presynaptic and long-lasting postsynaptic inhibition during penicillin-induced spinal seizures

JOHN DAVENPORT, M.D., PETER C. SCHWINDT, Ph.D. and WAYNE E. CRILL, M.D.

Seattle Veterans Administratlon Hospital Epilepsy Center, the Department of Physiology and Biophysics and the Department of Medicine (Neurology), University of Washington, Seattle, Washington.

In experiments on seven cats we tested the hypothesis that the epileptogenic effect of penicillin (PCN) on the spinal cord is mediated by a reduction of presynaptic inhibition. PCN-induced spinal hyperactivity was not associated with changes in either the presynaptic inhibition of extensor monosynaptic reflexes by conditioning volleys in flexor muscle nerves, or in evoked dorsal root potentials. Long-lasting inhibition of monosynaptic reflexes by repetitive cutaneous nerve volleys, shown by intracellular recording to be associated with prolonged inhibitory postsynaptic potentials (IPSPs), was also not changed by PCN. Antagonism of either pre- or postsynaptic spinal inhibition is not a necessary condition for induction of spinal seizures by PCN.

Dr Davenport's address is General Medical Research, Seattle Veterans Hospital. 4435 Beacon Avenue South, Seattle WA 98108.

This work was supported by Veterans Administration Research Grant MRlS 1610 and NINCDS Grant NS 05082.

Presented in part at the twenty-ninth annual meeting of the American Academy of Neurology, Atlanta April 1977.

Accepted for publication June 24, 1977.






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