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Meningiomas in five members of a family over two generations, in one member simultaneously with acoustic neurinomas

Ophthalmogenetic Department of the Netherlands Ophthalmic Research Institute, Wilhelmina Gasthuis, Amsterdam, The Netherlands.

Despite four reports of familial occurrence of meningiomas, the inheritance of this tumor remains an open question. We describe a family in which four members in two generations had meningiomas without evidence of neurofibromatosis. Another member of the family, however, had multiple meningiomas and bilateral acoustic neurinomas, while yet another had multiple cafe-au-lait spots. We suspect that a highly unusual presentation of neurofibromatosis explains this otherwise very unlikely occurrence.

Dr DeJong's address is Ophthalmogenetic Department of the Netherlands Ophthalmic Research Institute, Wilhelmina Gasthuis, Amsterdam, The Netherlands.

Accepted for publication June 10, 1977.