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Computerized cranial tomography in cerebral diseases of white matter

Departments of Radiology (Drs. Lane and Carroll) and Neurology (Dr. Pedley), Stanford University School of Medicine, Stanford, California.

Computerized tomographic scans were performed on 31 patients with primary diseases of the white matter. Among 18 patients with multiple sclerosis, acute lesions were visualized in five, all with symptomatic cerebral hemisphere disease. Characteristic white matter lesions were also demonstrated in adrenoleukodystrophy, spongiform encephalopathy, progressive multifocal leukoencephalopathy, disseminated necrotizing leukoencephalopathy, and an undiagnosed leukoencephalopathy associated with malignancy. Besides identifying white matter abnormalities, the CT scan patterns were often specific enough to help distinguish among the various etiologic possibilities for the abnormalities. Useful diagnostic characteristics included the anatomic distribution of lesions, mass effect, atrophic changes, and enhancement after contrast infusion.

Dr. Carroll's address is Department of Radiology S096C, Stanford University Medical Center, Stanford. CA 94305.

This study was supported in part by USPHS Grant NS-11075 from the National Institute of Neurological and Communicative Diseasesand Stroke.

Accepted for publication June 20, 1977.

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