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Psychotropic effects of carbamazepine in epilepsy

A double-blind comparison with phenytoin

Epilepsy Center, Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington.

The "psychotropic" effects of carbamazepine were evaluated with phenytoin (Dilantin) as reference agent in a counterbalanced, crossover study. Forty adult epileptics were given a series of neuropsychologic tests and the MMPl after 4 months on each agent. Most abilities were much the same with either anticonvulsant, but there were fewer errors with carbamazepine on mental tasks requiring attention and problem solving, and some improvement in emotional status was suggested. The findings were consistent with patient reports of improvement in alertness and mental functioning. These results combine with the excellent anticonvulsant properties of carbamazepine to support its use as an anticonvulsant.

Requests for reprints should be addressed to Dr. Dodrill, Epilepsy Center, Harborview Medical Center, University of Washington, Seattle, WA 98104.

This research was supported by NIH Contract N01-NS-0–2281 and Grant NS 04053, National Institute of Neurological and Communicative Disorders and Stroke, PHSIDHEW.

Accepted for publication March 25, 1977.

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