HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by ASKANAS, V. Articles by BENDER, A. N. Search for Related Content PubMed PubMed Citation Articles by ASKANAS, V. Articles by BENDER, A. N.

Acetylcholine receptors of aneurally cultured human and animal muscle

Institute for Rehabilitation Medicine, New York University Medical Center (Dr. Askanas), and Department of Neurology, Mt. Sinai Hospital (Dr. Bender), New York City: Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda (Dr. Engel): and Department of Neurology, University of Colorado Medical Center, Denver, Colorado (Dr. Ringel).

We describe the diffuse nonjunctional distribution of AChR molecules of aneurally cultured human and animal muscle and the influence of sera from myasthenia gravis patients and rabbits with experimental autoimmune myasthenia gravis on binding of BT to diffuse nonjunctional AChR. One-hour incubation of myasthenia gravis sera resulted in blocking of the -BT-immunoperoxidase staining of their AChRs, while incubation in normal sera did not. Aneurally cultured muscle can aid studies of regenerating fibers in normal muscle compared with those of muscles in neuromuscular diseases, and also act as an environmentally controlled test object for demonstrating the effect of circulating pathogenic factors.

Dr. Askanas' present address is Medical Neurology Branch, NINCDS, Bethesda, MD 20014.

Accepted for publication December 6, 1976.

This article has been cited by other articles:

				M. Foidart, J.-M. Foidart, and W. K. Engel Collagen Localization in Normal and Fibrotic Human Skeletal Muscle Arch Neurol, March 1, 1981; 38(3): 152 - 157. [Abstract] [PDF]

				W. K. Engel Dagen des Oordeels: Pathokinetic Mechanisms and Molecular Messengers (A Dramatic View) Arch Neurol, June 1, 1979; 36(6): 329 - 339. [Abstract] [PDF]

				B. T. Adornato, W. K. Engel, and M. Foidart-Desalle Elevations of Hemopexin Levels in Neuromuscular Disease Arch Neurol, September 1, 1978; 35(9): 577 - 580. [Abstract] [PDF]