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Cerebral blood flow, oxygen utilization, and blood volume in dementia

Department of Neurology and Neurological Surgery (Neurological Surgery) and Division of Radiation Sciences (Dr. Grubb); Department of Neurology and Neurological Surgery (Neurology) and Division of Radiation Sciences (Dr. Raichle); Division of Neuroradiology (Dr. Gado); Division of Radiation Sciences (Dr. Eichling); and Department of Neurology and Neurological Surgery (Neurology) (Dr. Hughes), The Edward Mallinckrodt Institute of Radiology, St. Louis, Missouri.

Patients with dementia had significant decreases in cerebral blood flow and cerebral oxygen utilization and a mild, but not significant, increase in cerebral blood volume. These studies were not useful in distinguishing patients with cerebral atrophy from patients with normal pressure hydrocephalus, as similar changes in cerebral circulation and metabolism were seen in both groups. Changes in cerebral blood flow after acute decrease in the intracranial pressure also were not helpful in differentiating patients with normal pressure hydrocephalus from patients with cerebral atrophy.

Reprint requests should be addressed to Dr. Grubb, Department of Neurology and Neurological Surgery, Washington University School of Medicine, 4901 Barnes Hospital Plaza, St. Louis, MO 63110.

Presented in part at the twenty-sixth annual meeting of the American Academy of Neurology, San Francisco, California, April, 1974.

This work was supported by U. S. PHS Grants No. HL13851 and NSO 6833 (NINDS); and by Teacher-Investigator Award No. NS11059 from NINDS (Dr. Raichle).

Accepted for publication February 1, 1977.

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