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NEUROLOGY 1976;26:797
© 1976 American Academy of Neurology

Viruslike particles in granulomatous angiitis of the central nervous system

MARCELINO G. REYES, M.D., R. FRESCO, M.D., Ph.D., S. CHOKROVERTY, M.B.B.S., M.R.C.P. and E. Q. SALUD, M.D.

From the Departments of Neurology and Pathology (Dr. Reyes), Experimental Pathology (Dr. Fresco), Mount Sinai Hospital Medical Center, Chicago; Oak Forest Hospital, Oak Forest, Illinois. (Dr. Reyes and Salud); and the Neurology Service, Veterans Administration Hospital, Hines, Illinois (Dr. Chokroverty).

Neuropathologic examination of the brain of a 67-year-old woman with a 5-month history of progressive multiple neurologic deficits showed granulomatous angiitis of the small parenchymal and leptomeningeal blood vessels of the brain and spinal cord. Electron microscopy of formalin-fixed brain disclosed intranuclear viruslike particles resembling herpesvirus. Although definitive proof cannot be established without further virologic tests, this previously unreported finding suggests that some cases of granulomatous angiitis of the central nervous system may result from viral infection.

Requests for reprints should be addressed to Dr. Reyes, Department of Neurology (Neuropathology), Mount Sinai Hospital Medical Center, California at 15th, Chicago, IL 60608.

Received for publication December 17, 1975.




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