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Prognostic factors in absence seizures

From the Epilepsy Branch, Neurological Disorders Program, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (Drs. Sato and Penry), and the Department of Neurology, University of Virginia School of Medicine, Charlottesville, Virginia (Dr. Dreifuss).

A prospective follow-up study was conducted on 48 epileptic patients (22 males and 26 females) who had participated in a collaborative study of absence seizures about 7 years earlier. Multivariate analysis showed that the significant prognostic factors for absence seizures were normal or above normal intelligence and normal electroencephalographic background activity. For any seizure type, significant prognostic factors were a negative history of generalized tonic-clonic seizures, normal or above normal intelligence, and a negative family history of seizure disorders. Nearly 90 percent of the patients with all significant prognostic factors for both absence seizures and seizures of all types ceased having seizures.

Requests for reprints should be addressed to Dr. Penry, Room 114, Federal Bldg., NINCDS, Bethesda, MD 20014.

This study was supported by NINCDS contract N01-9-2196 and by grant RR-304 from the General Clinical Research Centers Program of the Division of Research Resources, National institutes of Health.

Presented at the twenty-seventh annual meeting of the American Academy of Neurology, Bal Harbour, Florida, April 28-May 3, 1975.

Received for publication December 31, 1975.

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