HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by LEVINSON, A. I. Articles by ZWEIMAN, B. Search for Related Content PubMed PubMed Citation Articles by LEVINSON, A. I. Articles by ZWEIMAN, B.

Immunologic characterization of cerebrospinal fluid lymphocytes

Preliminary report

From the Department of Medicine, Allergy and Immunology Section, and Department of Neurology, School of Medicine, University of Pennsylvania, University of Pennsylvania-Wistar Institute Multiple Sclerosis Research Center, Philadelphia.

Cellular immunocompetence of cerebrospinal fluid lymphocytes was investigated in several neurologic diseases. Microtechniques were developed to enable determination of E-rosetting capacity and phytohemagglutinin responsiveness of scant numbers of cells present in the cerebrospinal fluid specimens studied. Although most individuals had phytohemagglutinin-responsive cells in their CSF, reactivity was somewhat less than that found simultaneously in their blood. Three of eight patients had comparable percentages of E rosettes in their blood and CSF. In the remainder, the values differed significantly. Although preliminary, these results illustrate a new approach to immunologic characterization of CSF lymphocytes in diseases.

This study was supported by USPHS grants Nos. 5 P01 NS11037-02, 5 K07-NS11061-03, and 5 T01A1-00319 and National Multiple Sclerosis Society 894-A-2.

Received for publication September 9, 1975.

Dr. Lisak's address is Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104.

This article has been cited by other articles:

				H. W. Querfurth and E. J. Mark Case 8-1998- A 41-Year-Old Man with Leg Weakness and Mediastinal Lymphadenopathy N. Engl. J. Med., March 12, 1998; 338(11): 747 - 754. [Full Text] [PDF]