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Myoclonus after 5-hydroxytryptophan in rats with lesions of indoleamine neurons in the central nervous system

From the Psychiatric Research Laboratories, Department of Psychiatry, Laboratory of Clinical Neurophysiology, and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.

A myoclonic syndrome consisting of tremor, myoclonus, and seizures was produced following the systemic administration of 5-hydroxytryptophan to adult rats previously given intracisternal injections of 5, 7-dihydroxytryptamine and systemic desmethylimipramine, but not in their controls. This behavioral response was blocked by pretreatment with the putative serotonin receptor blocking agents methysergide, lysergic acid diethylamide, and bromolysergic acid diethylamide, as well as centrally effective doses of the aromatic amino acid decarboxylase inhibitor Ro4-4602. Blockers of receptors of other neurotransmitters had little effect. This neurologic response in the adult rat may be relevant to some forms of clinical myoclonus and may be useful in testing potential agonists and antagonists of serotonin receptors in the mammalian central nervous system.

This work was supported in part by research grants from the United States Public Health Service (NIMH: MH-16674, MH-25515) and the Allen P. and Josephine B. Green Foundation as well as post doctoral fellowship (MH-02125) to Dr. Stewart, research career scientist award (MH-47370) to Dr. Baldessarini, and the MGH Parkinson Fund Award to Dr. Growdon.

Received for publication November 26, 1975.

Dr. Stewart's address is Psychiatric Research Laboratories, Massachusetts General Hospital, Boston, MA 02114.

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