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NEUROLOGY 1976;26:664
© 1976 American Academy of Neurology

Experimental alterations in cyclic adenosine monophosphate concentrations in the cat basilar artery

EUGENE S. FLAMM, M.D., ANNA T. VIAU, Ph.D., JOSEPH RANSOHOFF, M.D. and N. ERIC NAFTCHI, Ph.D.

From the Departments of Neurosurgery and Biochemical Pharmacology, New York University Medical Center, New York, New York.

Levels of cyclic adenosine monophosphate (AMP) in the basilar artery and in circulating blood of cats were determined after the production of spasm by topical application of blood to the vessel and following treatment with agents known to alter cyclic AMP. Isoproterenol, known to stimulate adenyl cyclase, and aminophylline, a phosphodiesterase inhibitor, were studied alone and in combination. Cyclic AMP of the basilar artery fell from a mean control value of 43 to 26 pmoles per milligram of protein following the production of vasospasm. Intravenous administration of isoproterenol alone and in combination with aminophylline produced dilatation of the basilar artery, which was associated with a marked rise in the cyclic AMP concentration in the vessel. The finding that cerebral vasospasm is associated with a fall and vasodilatation with a rise in cyclic AMP concentration supports the hypothesis of an active role for cyclic nucleotides in the regulation of cerebrovascular smooth muscle tone.

Dr. Flamm's address is 340 East 24th Street, New York, NY 10010.

This study was supported in part by the Edmond A. Guggenheim Clinical Research Endowment Fund.

Presented in part at the Seventh International Symposium on Blood Flow and Metabolism in the Brain, Aviemore, Scotland, June 17-20, 1975.

Received for publication October 23, 1975.






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