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NEUROLOGY 1976;26:656
© 1976 American Academy of Neurology

Melanosis of the choroid plexus

SAMRUAY SHUANGSHOTI, M.D., PAIBOON PAISUNTORNSOOK, M.D. and MARTIN G. NETSKY, M.D.

From the Departments of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, and Vanderbilt University School of Medicine, Nashville, Tennessee.

A unique case of melanosis of the choroid plexus in a 74-year-old man who died of hypertensive cardiovascular disease is described. The cerebral lesion did not cause symptoms. The proposed pathogenesis is the conversion of choroidal epithelial lipofuscin into melanin. Our findings also may explain the origin of a previously reported primary malignant melanoma of the choroid plexus and of black cortical adenomas of the adrenal gland.

Dr. Netsky's address is Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232.

Received for publication October 29, 1975.






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