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Measles antibodies as related to HL-A types in multiple sclerosis

From the Departments of Clinical Neurological Sciences (Dr. Paty), Community Medicine and Epidemiology (Dr. Rand), and Medicine (Dr. Stiller), University Hospital, The University of Western Ontario, London, and the Bureau of Biologics, Drugs Directorate, (Drs. Furesz and Boucher), Ottawa, Canada.

One hundred thirty-six patients with multiple sclerosis and several control groups were studied for measles antibodies using several different antigens. Measles antibodies were higher in the multiple sclerosis population, but siblings also had higher titers than matched and random controls. The elevation in antibody titers (complement fixation) was found in female multiple sclerosis patients and male patients with HL-A types 3, 7, and W-18. Male patients not carrying these HL-A antigens had, as a group, relatively normal antibody levels. These data confirm a familial factor in elevated measles antibody titers. We suggest that HL-A antigens are linked to one of the factors that determines measles antibody titers in multiple sclerosis patients.

Dr. Paty's address is University Hospital, 339 Windermere Road, London, Ontario N6G 2K3, Canada.

This paper was presented at the twenty-seventh meeting of the American Academy of Neurology, May 1975, Bal Harbour, Florida, with additional portions presented at the tenth Canadian Congress of Neurological Sciences, June 1975, London, Ontario.

Received for publication August 25, 1975.

This article has been cited by other articles:

				R. J. Kascsak, R. E. Shope, H. Donnenfeld, and H. Bartfeld Antibody Response to Arboviruses: Absence of Increased Response in Amyotrophic Lateral Sclerosis and Multiple Sclerosis Arch Neurol, July 1, 1978; 35(7): 440 - 442. [Abstract] [PDF]