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Amino acid abnormalities in cerebrospinal fluid of patients with parkinsonism and extrapyramidal disorders

From the Department of Neurology, University Hospital, Groningen, The Netherlands.

Free amino acid determinations in the cerebrospinal fluid of patients with Parkinson's disease or other extrapyramidal disorders showed that in both groups most amino acids were increased. Significantly increased amino acids were neutral and basic amino acids. Amino acid clusters were present and corresponded with the grouping of amino acids in accordance with amino acid transport Systems. The amino acids within the clusters showed a remarkable degree of correlation, and there was a notable correlation between the clusters both in the parkinsonian group and in the group of extrapyramidal disorders, but not in a control group. Our data suggest that in a number of extrapyramidal disorders, Parkinson's disease included, amore generalized abnormality exists than neuronal loss only and, in addition, that patients with these neurologic conditions have a common biochemical defect in their amino acid transport Systems.

Part of this work was presented at the meeting of the Fulton Society, New York, May 31, 1975.

Received for publication July 9, 1975.

Dr. Lakke's address is Department of Neurology, University Hospital, Groningen, The Netherlands.

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