HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by VARDI, Y. Articles by ZOR, U. Search for Related Content PubMed PubMed Citation Articles by VARDI, Y. Articles by ZOR, U.

Migraine attacks

Alleviation by an inhibitor of prostaglandin synthesis and action

From the Department of Neurology, Municipal Governmental Medical Center, Ichilov Hospital, Tel Aviv University Medical School, the Department of Obstetrics and Gynecology, Zahalon Governmental Hospital, Tel Aviv-Jaffa, and the Department of Hormone Research, the Weizmann Institute of Science, Rehovot, Israel.

Twenty-six patients with migraine attacks were treated for 3 to 16 months with flufenamic acid (125 mg four to six times per attack), an inhibitor of prostaglandin synthesis and action. In 25 patients the drug afforded symptomatic relief in 195 of 200 treated attacks. Side effects observed were mild dyspepsia (eight patients) and severe upper gastrointestinal symptoms (two patients). None of the eight patients treated with placebo reported any relief (20 attacks). The "common" antimigraine drugs afforded symptomatic relief in 12 of the patients, partial relief in seven, and no relief in seven. Treatment with flufenamic acid was based on the hypothesis that prostaglandins are involved in migraine attack and that the drug relieves migraine by inhibition of the vasoactivity of prostaglandins.

Requests for reprints should be addressed to U. Zor, Ph.D., Department of Hormone Research, the Weizmann Institute of Science, Rehovot, Israel.

Received for publication May 27, 1975.

This article has been cited by other articles:

				D. K. Ziegler and D. J. Ellis Naproxen in Prophylaxis of Migraine Arch Neurol, June 1, 1985; 42(6): 582 - 584. [Abstract] [PDF]