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Arachidonate-induced cerebrovascular occlusion in the rat

The role of platelets and aspirin in stroke

From the Department of Neurology, University of Virginia School of Medicine, Charlottesville.

Unilateral cerebrovascular occlusion was produced in heparinized rats within seconds after injection of microgram quantities of sodium arachidonate into the internal carotid artery. Electroencephalographic activity over the affected cerebral hemisphere became attenuated, and cerebral blood flow decreased by half. A neurologic syndrome, including ipsilateral blindness and contralateral sensorimotor deficits, resulted from occlusion of the microvasculature by platelet thrombi. Although aspirin strongly inhibited arachidonate-induced platelet aggregation in vitro, the drug offered little protection against arachidonate-induced stroke.

Dr. Bass's address is Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA 22901.

This invesigation was supported by USPHS training grant No. 05120 and a Research Career Development Award (NS 28155) to Dr. Bass.

Presented in part at the annual meeting of the American Academy of Neurology, Miami, Florida, May 1975, and selected for honorable mention for the 1975 S. Weir Mitchell Award.

Received for publication July 14, 1975.

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