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NEUROLOGY 1976;26:1182
© 1976 American Academy of Neurology

Erythrocyte shape in Duchenne muscular dystrophy

D. W. MATHESON, Ph.D., W. K. ENGEL, M.D. and E. C. DERRER, M.A.

From the Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland.

In a controlled and blind study we were not able to identify any abnormality of erythrocytes of eight patients with Duchenne muscular dystrophy compared with seven approximately age-matched unaffected siblings (six males, one female step-sibling). Erythrocyte morphology was found to be very sensitive to various types of cell treatment. At this time, erythrocyte morphology, evaluated by the techniques used, should not be considered an established diagnostic test for the Duchenne muscular dystrophy patient or carrier.

Dr. Engel's address is Medical Neurology Branch, NINCDS, Bethesda, MD 20014.

Received for publication March 10, 1976.




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