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Brain serotonin concentration and crude synaptosomal uptake in mice with the Chediak-Higashi syndrome

From the Department of Veterinary Physiology and Pharmacology, Washington State University, Pullman, Washington.

The Chediak-Higashi syndrome is characterized by a serotonin platelet defect and neuronal dysfunction. Whole blood serotonin concentration, serotonin brain concentration, and synaptosomal uptake of serotonin were determined in mice with the syndrome. While brain serotonin uptake in the affected mice was not significantly different from that in nonaffected mice, whole blood serotonin concentration was markedly reduced. These data suggest that in human neuropathies with platelet serotonin defect, a parallel neuronal serotonin disorder may not be assumed.

Requests for reprints should be addressed to Dr. Meyers, Department of Veterinary Physiology and Pharmacology, Washington State University, Pullman, WA 99163.

This study was supported by Washington State Medical and Biological fund, 13B-2550-0555 and NH grant No. RR 00515.

Received for publication January 15, 1976.