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On the movement of fluid through the brain of hydrocephalie cats

From the Departments of Neurosurgery (Drs. Marlin and Wald) and Neurology (Dr. Hochwald and Mr. Malhan), New York University Medical Center, New York.

The effects of changes in serum osmolality on the volume flow of fluid into the cerebral ventricles and on brain water content was examined in cats with kaolin-induced hydrocephalus. Slopes of the regression lines relating volume flow and serum osmolality for both normal and hydrocephalie cats are the same. The constant difference in flow rates between the two lines, 7 µl per minute, is probably due to impaired choroid plexus function of the hydrocephalie cats. The osmotic pressure gradient that causes the flow of fluid is therefore probably between blood and brain. Under these conditions, changes in brain water content of hydrocephalie cats were smaller than in normals and can be related to the edema present in this disorder. Despite the inflammatory response to kaolin, the blood-brain barrier remains intact. From the calculated filtration coefficient, it can be inferred that the flow of water from serum through brain and into cerebrospinal fluid is limited by the resistance of fluid flow through the brain.

Received for publication February 24, 1976.