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NEUROLOGY 1976;26:1124
© 1976 American Academy of Neurology

Sacral agenesis

Neurologic and neuropathologic features

HARVEY B. SARNAT, M.D., MARY E. CASE, M.D. and RICHARD GRAVISS, M.D.

From the Departments of Neurology (Dr. Sarnat), Pathology (Dr. Case), Pediatrics (Drs. Sarnat and Graviss), and Radiology (Dr. Graviss), St. Louis University School of Medicine and Cardinal Glennon Memorial Hospital for Children, St. Louis, Missouri.

The neurologic deficits in sacral agenesis involve motor function much more than sensory function, in a lumbosacral distribution; autonomic involvement, with neurogenic bladder, is variable. Relative sensory sparing may be due to the derivation of sensory nerves from neural cret tissue, which is uninvolved. An occult sacral meningomyelocele with ectopic neural tissue was found at necropsy in one of our patients. Primary amyoplasia may account for small but histologically normal muscles derived from the same somites as the aplastic vertebrae.

Requests for reprints should be addressed to Dr. Sarnat, Section of Neurology, Princess Margaret Hospital for Children, Perth, Western Australia 6001.

Received for publication December 22, 1975.




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