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Autopsy correlations of computerized tomography

Experience with 6,000 CT scans

From the Dent Neurologic Institute, Millard Fillmore Hospital, and State University of New York School of Medicine at Buffalo, New York.

Seventy-nine autopsy correlations of CT scans showed (1) excellent correlations in normal brains, but the size of the lateral ventricles consistently larger during life than after death; (2) a distinctive pattern differentiating obstructive from nonobstructive hydrocephalus; (3) infarctions appearing as areas of decreased densities of parenchyma in vascular distributions; (4) distinctive high density appearances of hemorrhages that differentiated them from infarctions and, in general, all other pathologic processes; (5) supratentorial, intraventricular, and posterior fossa tumors appearing as masses that displaced, distorted, collapsed, and enlarged normal spaces and structures such as ventricles and pineal gland; (6) 11 false-negative CT scans in some cases of brain stem infarction, brain stem hemorrhage, and small metastasis; and (7) an overall accuracy of 86.2 percent of CT scanning in correctly identifying pathology of the brain.

Reprint requests should be addressed to Dr. Jacobs, Dent Neurologic Institute, Millard Fillmore Hospital, 3 Gates Circle, Buffalo, NY 14209.

Presented in part at the twenty-eighth annual meeting of the American Academy of Neurology, May 1, 1976, Toronto, Canada.

This study was supported in part by grants from the Harry M. Dent Family Foundation, Inc., and the Jacobs Family Foundation, Inc.

Received for publication June 4, 1976.

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