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Penicillin transport from cerebrospinal fluid

From the Royal Postgraduate Medical School, London, England, and the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Department of Health, Education, and Welfare, Bethesda, Maryland.

The passage of penicillin G from cerebrospinal fluid (CSF) was studied by continuous ventriculocisternal perfusion in conscious rabbits. The concentration of penicillin G in the perfusate, collected from the cisterna magna, was 76.5 percent ± 1.0 (SEM) of that entering the ventricles (having adjusted for normal secretion of CSF). The mean concentration of penicillin G rose 15 percent (p < 0.005) in the cisternal CSF after probenecid (2 mg per milliliter) was added to the perfusion fluid. We conclude that an active transport system removes penicillin G from the CSF; this mechanism can be inhibited by intraventricular probenecid. Our results are in accord with observations deriving from studies on anesthetized animals given probenecid intravenously or intraperitoneally.

Requests for reprints should be addressed to Dr. Calne, Bldg. 10, Rm 6D20, National Institute of Health, Bethesda MD 20014.

Received for publication January 16, 1976.