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Effects of neonatal status epilepticus on rat brain development

From the Department of Neurology, Cornell University Medical College, 1300 York Avenue, New York, New York.

A single, 2-hour episode of status epilepticus induced by flurothyl (1,500 µl) in 4-day-old rats irreversibly curtailed brain weight and brain DNA. Status epilepticus inhibited DNA synthesis but did not increase DNA breakdown and produced no histologic lesions. Rats with status epilepticus showed delayed behavioral milestones and reduced seizure thresholds several weeks after status. After milder convulsions (flurothyl 750 $mUl, bicuculline), brain DNA was curtailed at 7 days but returned to normal at 30 days. These results suggest that, in the immature brain, epileptic seizures too mild to cause cell necrosis can inhibit DNA synthesis and permanently curtail brain DNA content. This may account for the great vulnerability of the immature brain to epileptic seizures.

Dr. Wasterlain's address is Department of Neurology, UCLA-San Fernando Valley Medical Program, Sepulveda Veterans Administration Hospital, Sepulveda, CA 91343.

This study was supported by Research Career Development Award No. NS 70634 and NINCDS Research Grant No. NS 09625.

Received for publication December 4, 1975.

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