Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CARPENTER, S.
Right arrow Articles by WATTERS, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CARPENTER, S.
Right arrow Articles by WATTERS, G.
NEUROLOGY 1976;26:952
© 1976 American Academy of Neurology

The childhood type of dermatomyositis

STIRLING CARPENTER, M.D., GEORGE KARPATI, M.D., STANLEY ROTHMAN, M.D. and GORDON WATTERS, M.D.

From the departments of Neurology-Neurosurgery and Pediatrics, McGill University, The Montreal Neurological Institute, and Montreal Children's Hospital, Montreal, Quebec, Canada.

The childhood type of dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, lymphocytes, pericytes, and pseudosatellite cells. The muscle fiber damage is coextensive with capillary damage and probably results from progressive ischemia. The muscle cells, before atrophying, show mitochondrial elongation, Z disk streaming, focal myofibrillary loss, and occasionally selective thick filament loss. Muscle cell necrosis is rare and limited to infarctlike lesions. Inflammatory infiltrates, if present, occur only in connective tissue septa. The cause of the capillary damage has not been determined.

Dr. Carpenter's address is Montreal Neurological Institute, 3801 University St., Montreal, Quebec, Canada H3A 2B4.

This study was supported in part by The Medical Research Council of Canada, and The Isaac Walton Killam Memorial Fund of The Montreal Neurological Institute, and The Muscular Dystrophy Association of Canada.

Received for publication July 28, 1975.




This article has been cited by other articles:


Home page
 NeurologyHome page
S. A. Greenberg
Proposed immunologic models of the inflammatory myopathies and potential therapeutic implications
Neurology, November 20, 2007; 69(21): 2008 - 2019.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
C.-Y. Tsao, J. R. Mendell, and J. T. Kissel
Dermatomyositis in Two Siblings and a Brief Review of Familial Dermatomyositis
J Child Neurol, July 1, 2002; 17(7): 540 - 542.
[Abstract] [PDF]

Home page
 Ann Rheum DisHome page
O. Backhouse, B. Griffiths, T. Henderson, and P. Emery
Ophthalmic manifestations of dermatomyositis
Ann Rheum Dis, August 1, 1998; 57(8): 447 - 449.
[Full Text]

Home page
 J Child NeurolHome page
C. Jimenez, P. C. Rowe, and D. Keene
Cardiac and Central Nervous System Vasculitis in a Child With Dermatomyositis
J Child Neurol, July 1, 1994; 9(3): 297 - 300.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
J.M. Slopis, E.F. Jackson, P.A. Narayana, S.C. Papasozomenos, and I.J. Butler
Proton Magnetic Resonance Imaging and Spectroscopic Studies of the Pathogenesis and Treatment of Juvenile Dermatomyositis
J Child Neurol, July 1, 1993; 8(3): 242 - 249.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
R. C. Griggs and G. Karpati
The Pathogenesis of Dermatomyositis
Arch Neurol, January 1, 1991; 48(1): 21 - 22.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
J. T. Kissel, R. K. Halterman, K. W. Rammohan, and J. R. Mendell
The Relationship of Complement-Mediated Microvasculopathy to the Histologic Features and Clinical Duration of Disease in Dermatomyositis
Arch Neurol, January 1, 1991; 48(1): 26 - 30.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
M. F. Gonzales, R. K. Olney, Y. T. So, C. M. Greco, B. A. McQuinn, R. G. Miller, and S. J. DeArmond
Subacute Structural Myopathy Associated With Human Immunodeficiency Virus Infection
Arch Neurol, May 1, 1988; 45(5): 585 - 587.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
H. M. Schroter, H. B. Sarnat, D. S. Matheson, and T. P. Seland
Juvenile Dermatomyositis Induced by Toxoplasmosis
J Child Neurol, April 1, 1987; 2(2): 101 - 104.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
S. P. Ringel, M. R. Carry, A. J. Aguilera, and J. M. Starcevich
Quantitative Histopathology of the Inflammatory Myopathies
Arch Neurol, October 1, 1986; 43(10): 1004 - 1009.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
I. Halperin, I. Kobrin, M. Ilsar, G. Lugassy, and R. Yarom
Thick-Filament Degeneration Associated With Periarteritis Nodosa
Arch Neurol, November 1, 1982; 39(11): 730 - 732.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
D. Chad, P. Good, L. Adelman, W. G. Bradley, and J. Mills
Inclusion Body Myositis Associated With Sjogren's Syndrome
Arch Neurol, March 1, 1982; 39(3): 186 - 188.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
P. C. Dau
Plasmapheresis in Idiopathic Inflammatory Myopathy: Experience With 35 Patients
Arch Neurol, September 1, 1981; 38(9): 544 - 552.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
J. L. Bennington and P. C. Dau
Patients With Polymyositis and Dermatomyositis Who Undergo Plasmapheresis Therapy: Pathologic Findings
Arch Neurol, September 1, 1981; 38(9): 553 - 560.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by AAN Enterprises, Inc.