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Central monoamines and hyperkinesis of childhood

From the Section of Reproductive and Developmental Medicine, Brown University Program in Medicine, and the Divisions of Pediatrics and Neurology, The Miriam Hospital, Providence, Rhode Island (Dr. Shetty), and the Laboratory of Neuropharmacology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland (Dr. Chase).

Article abstract—Lumbar cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid, the major metabolites of dopamine and serotonin, respectively, in hyperactive children did not differ significantly from those of age-matched controls. Dextroamphetamine treatment substantially reduced the spinal fluid content of homovanillic acid but not of 5-hydroxyindoleacetic acid. No change in levels of either monoamine metabolite occurred with placebo therapy. In hyperactive children receiving dextroamphetamine, the amount of homovanillic acid decline correlated closely with the degree of clinical improvement. These results support the view that an alteration in central dopamine-mediated synaptic function may occur in children manifesting the hyperactive syndrome.

Dr. Shetty's address is Section of Reproduction and Developmental Medicine, Brown University, 50 Maude St., Providence, RI 02908.

Received for publication December 3, 1975.

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