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NEUROLOGY 1975;25:891
© 1975 American Academy of Neurology

In vitro cellular responsiveness in multiple sclerosis patients to a viral isolate from multiple sclerosis brain tissue and to other antigens

A. KENNETH CIONGOLI, D.O., ROBERT P. LISAK, M.D., BURTON ZWEIMAN, M.D., HILARY KOPROWSKI, M.D. and DAVID WATERS, Ph.D.

Department of Neurology and Division of Allergy and Immunology, Department of Medicine, School of Medicine, University of Pennsylvania and the Multiple Sclerosis Research Center of the Department of Neurology and Wistar Institute, Philadelphia.

The Clausen modification of the leukocyte migration test was used to test patients with multiple sclerosis, normal subjects, and patients with other neurologic diseases for cell-mediated immunity to 6/94 virus (a parainfluenza virus previously isolated from the brain tissue of a multiple sclerosis patient), c-RNA virus isolated from a tumor, and the nonviral antigens Candida and purified protein derivative. Leukocytes of multiple sclerosis patient showed significantly less mean inhibition of migration by the 6/94 virus (but not by the c-RNA virus, purified protein derivative, and Candida) than did the cells of normal controls and patients with other neurologic diseases. The relationship of these findings to previous observations in this area and to the pathogenesis of multiple sclerosis is discussed.

This study was supported by USPHS grants No. 5 PO1 NS11037–02. NS11036, 5 T01A1–00319, and National Multiple Sclerosis Society grant 894-A-2.

Received for publication February 24, 1975.

Dr. Ciongoli's address is Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104.






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