HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by MOSELEY, J. I. Articles by MOLINARI, G. F. Search for Related Content PubMed PubMed Citation Articles by MOSELEY, J. I. Articles by MOLINARI, G. F.

Barbiturate attenuation of the clinical course and pathologic lesions in a primate stroke model

Section on Head Injury and Stroke, Stroke Models Laboratory, National Institute of Neurological and Communicative Disorders and Stroke. Received for publication February 21, 1975.

To evaluate the potential for clinical application, the reputed protective action of barbiturates in cerebral ischemia was tested in a controlled study after segmental middle cerebral artery occlusion in primates. Surviving treated animals promptly recovered consciousness, locomotion, and feeding behavior despite persistent hemiplegia, while control animals ran an indolent course, with slow recovery of poor quality. Cerebral lesions in treated animals were confined to the deep hemispheric structures, while control specimens showed larger deep lesions confluent with extensive areas of cortical infarction. These results are less dramatic than those reported by others, but the protective effect observed in fields of collateral circulation deserves further exploration as an adjunct to medical and surgical management.

Requests for reprints should be addressed to Dr. Molinari, National Institutes of Health, Building 36, Room 4A03, Bethesda, MD 20014.

This article has been cited by other articles:

				K. M. Erickson and W. L. Lanier Anesthetic Technique Influences Brain Temperature, Independently of Core Temperature, During Craniotomy in Cats Anesth. Analg., May 1, 2003; 96(5): 1460 - 1466. [Abstract] [Full Text] [PDF]