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Effect of hypertonic solutions on the blood-brain barrier

Division of Neurosurgery, University of New Mexico School of Medicine and the Veterans Administration Hospital, Albuquerque, New Mexico.

The effect of hypertonic urea and saline on the blood-brain barrier of the dog was quantitatively measured by the indicator diffusion technique. Urea appeared to stimulate glucose transport into the brain, while the diffusionary loss of fructose was enhanced. Hypertonic saline affected the diffusionary loss of the test sugars in a similar manner, but had no effect on glucose transport. The blood-brain barrier alterations were not reversible, but did decrease somewhat with time.

This study was supported by grant No. CA14910 from the National Institutes of Health.

Received for publication February 18, 1975.

Dr. Pollay's address is Division of Neurosurgery, University of New Mexico School of Medicine, 915 Stanford Drive, NE, Albuquerque, NM 87131.

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