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Cellular hypersensitization to peripheral nervous antigens in the Guillain-Barré syndrome

Montreal Neurological Institute, and the Department of Neurology, McGill University, Montreal, Quebec.

The macrophage migration inhibition factor assay was used as a specific measure of cellular hypersensitivity to peripheral nervous system antigen in a large group of Guillain-Barré patients and control subjects. Lymphocytes from 34 patients with Guillain-Barré syndrome, 33 with other peripheral nervous system disease, and 33 normal controls were assayed for production of macrophage migration inhibition factor. A mean of 101 ± 7.2 was obtained in the control group, 70 ± 16.3 in the Guillain-Barré syndrome group, and 96 ± 11.3 in those with other peripheral nervous system disease. Twenty-six of the 34 patients with Guillain-Barré syndrome, two patients with myeloradiculitis, and two with Bell's palsy gave significant values. These results support the hypothesis that cellular hypersensitization to peripheral nervous system antigens is a pathogenetic factor in Guillain-Barré syndrome.

This work was supported by the Medical Research Council of Canada. Received for publication February 5, 1975.

Reprint requests should be addressed to Dr. Sheremata, Montreal Neurological Hospital, 3801 University St., Montreal H3A 2B4, Que., Canada.

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