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Progressive multifocal leukoencephalopathy

A complication of immunosuppressive treatment

Departments of Medicine and Neurology, Kaiser-Permanente Medical Center, Walnut Creek, California, and the Pathology Department, University of California, San Francisco.

Progressive multifocal leukoencephalopathy developed in a patient with rheumatoid arthritis after treatment with an immunosuppressive agent (chlorambucil). We feel that this case lends further support to the concept that an altered immunologic state is important in the appearance of this infection, which is probably viral in origin.

Received for publication December 10, 1974.

Reprint requests should be addressed to Dr. Sponzilli, Department of Medicine, Kaiser-Permanente Medical Center, 1515 Newell Avenue, Walnut Creek, CA 94596.

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