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Chronic cerebellar stimulation in the monkey

Electron microscopic and biochemical observations

Departments of Pathology (Division of Neuropathology) and Neurology, Columbia University College of Physicians and Surgeons, New York City.

The effects of chronic electrical stimulation to the surface of cerebellum in the Macaca mulatta monkey were studied with morphologic and biochemical techniques. There was considerable damage and loss of Purkinje cells in all specimens examined, including an area without electrodes, but the greatest changes appeared in tissue beneath the cathode and anode. Despite the damage, normal appearing synapses persisted in the molecular layer of all specimens. Fibrous glial processes were more numerous beneath the cathode. There were abnormalities in gamma-amino butyric acid (GABA) and polyamine concentrations in virtually all specimens, consistent with the morphologic evidence of widespread tissue damage.

This study was supported in part by grants from the Epilepsy Foundation of America and the Parkinson's Disease Foundation and by USPHS grants NS 05184, NS 11766, and NS 11981.

Received for publication November 4, 1974.

Dr. Tennyson's address is Department of Neurology, Room 342 Black Building, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032.