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Neuromuscular complications of acromegaly

Departments of Neurology and Medicine and the Metabolic Research Unit, University of California School of Medicine, San Francisco, California.

Seventeen consecutive acromegalic patients were evaluated for evidence of neuromuscular dysfunction and followed for 1 year after hypophysectomy. Before treatment, four patients had both a myopathy and the carpal tunnel syndrome, five had myopathy alone, four had carpal tunnel syndrome alone, and four had neither. The myopathy was characterized by mild, strictly proximal weakness and flabbiness of muscles; electromyography revealed typical myopathic abnormalities, but serum enzymes and muscle biopsy usually were normal. The presence of myopathy or the carpal tunnel syndrome could not be correlated with the magnitude of growth hormone elevation or any secondary endocrine derangement, but myopathy was associated with a longer duration of acromegaly. Carpal tunnel symptoms usually improved in the first 6 weeks after hypophysectomy, while myopathy improved more slowly and sometimes was detectable 1 year later.

This paper was presented in part before the twenty-fifth annual meeting of the American Academy of Neurology in Boston, April 1973.

Received for publication December 20, 1974.

Dr. Layzer's address is Department of Neurology, University of California, San Francisco, CA 94143.

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