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"Encephalomyeloneuritis" in the absence of cancer

Departments of Neurology and Pathology (Neuropathology), Stanford University School of Medicine and Veterans Administration Hospital, Palo Alto, California.

An elderly man presented with signs and symptoms indicating a rapidly progressive central and peripheral nervous system disease, which led to death within 3 months. The pathologic picture was that of a "paraneoplastic" encephalomyelitis and neuritis, but no cancer could be found. Supratentorial predilection for the limbic structures correlated well with an observed limbic dementia. Arguments favoring a direct toxic or metabolic effect of cancer as a cause for this syndrome are less convincing in view of this report.

This work was supported by NINDS neurology training grant 5 T01 NS-05254 and by the Veterans Administration Medical Research Program.

Received for publication August 30, 1974.

Dr. Langston's present address is Division of Neurology, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128.

This article has been cited by other articles:

				S. H. Gultekin, M. R. Rosenfeld, R. Voltz, J. Eichen, J. B. Posner, and J. Dalmau Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients Brain, July 1, 2000; 123(7): 1481 - 1494. [Abstract] [Full Text] [PDF]