HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by TANAKA, J. Articles by VILORIA, J. E. Search for Related Content PubMed PubMed Citation Articles by TANAKA, J. Articles by VILORIA, J. E.

Unusual demyelinating disease

A form of diffuse-disseminated sclerosis

Departments of Pathology and Neurology, University of Maryland School of Medicine, and Loch Raven Veterans Administration Hospital, Baltimore.

A young man, in good health until the age of 22, developed progressive personality changes, lethargy, motor difficulties, urinary bladder dysfunction, and convulsions. Spinal fluid abnormalities included monocytic pleocytosis and selective increase of gamma globulins. The clinical features and the structural lesions in the central nervous system are reminiscent of disseminated-diffuse sclerosis. Oligodendrocytes appeared normal in number and showed nonspecific abnormalities. Comparison of the structural lesions found in this case with those described in several reports of demyelination indicates that the separation of this syndrome, as a distinct entity, may not be justified. We suggest that such cases be classified as myelinoclastic disorders, in the same category with multiple sclerosis and its variants.

Received for publication October 28, 1974.

Reprint requests should be addressed to Julio H. Garcia, M.D., University of Maryland Hospital, 22 S. Greene Street, Baltimore, MD 21201.